PROTECTIVE EFFECT OF COCCINIA INDICA LEAF EXTRACT AGAINST ALCOHOL COMBINED WITH CARBON TETRACHLORIDE AND PARACETAMOL INDUCED LIVER DAMAGE IN RATS

Liver is a major metabolic organ affected by various toxins and chemicals. So  the potential therapeutic agent is needed for the  treatment of liver diseases. Natural products are the best source of remedies for the treatment of  all diseases.The aim of our study was to investigate the effect of leaf extract of Coccinia indica against Alcohol combines with CCl₄ and Paracetamol induced hepatotoxicity.The effects of oral treatment with Coccinia indica (CI) leaf extracts (100mg/kg and 200mg/kg  for 7 days) were studied on hepatic damage induced by alcohol (40% alcohol 2.0ml/100g, p.o. for 21 days) and  CCl₄ (0.1ml/kg, s.c. on 20^th day) and also with paracetamol ( 750mg/kg ip.) in rats.  Biochemical parameters in serum like glutamate oxaloacetate transaminase (SGOT), total Billirubin (TB), Alkaline phosphatase (ALP) and total proteins (TP) were estimated to assess the liver function. Alcohol – CCl₄ and paracetamol treatment produced an increase in SGOT, ALP, Total billirubin and decrease in total proteins indicating the liver damage.  These effects were progressively reduced (SGOT, ALP and Total billirubin) and increased (Total proteins) by treatment doses of (100mg/kg and 200mg/kg) CI leaf extracts. These biochemical observations were supplemented by histopathological examination of liver sections. CI leaf extract protected the liver from alcohol-CCl₄ and paracetamol induced hepatic damage