PROTECTIVE EFFECT OF NYCTHANTHES ARBOR-TRISTIS ON SCOPOLAMINE INDUCED AMNESIA IN RATS “A BEHAVIOURAL AND BIOCHEMICAL APPROACH”Abstract
The hydroalcoholic extract of Nyctanthes arbor-tristis (HeNAT) leaf was prepared using Soxhlet apparatus. Memory impairment (amnesia) in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time (TLT) in EPM model; escape latency time (ELT) and time spent in Q4 target quadrant (TSTQ) in MWM model. Scopolamine markedly decreased the TLT over 2 min, ELT, TSTQ over 90 sec and consecutively impaired learning and memory. HeNAT leaf extract (20 and 40 mg/kg, p.o.) increased the TLT, ELT, TSTQ and improved memory. Higher levels of brain AChE, MDA and NO and lower level of GSH activity were observed in scopolamine treated rats, which were significantly attenuated by HeNAT leaf extract. It is concluded that the leaf extract exhibited a significant nootropic effect in scopolamine induced impairment of memory in rats. Nootropic effect of the plant leaf extract may be mediated through the inhibition of oxidative stress and due to presence of iridoid and phenylpropanoid glycosides which was reported to possess anti-cholinesterase activity
Sonakshi Antal , Vrish Dhwaj Ashwlayan * and Anuj Kumar
Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.
29 August, 2016
16 November, 2016
01 December, 2016
01 March, 2017