PROTECTIVE EFFECT OF QUERCETIN ON BISPHENOL A – INDUCED ENZYMATIC CHANGES IN TESTIS OF MICE

Bisphenol A is well known endocrine disturbing chemical. Evidence has demonstrated that exposure to certain levels can cause toxic effect in humans and laboratory animal models. Quercetin is consistently the most active of the flavonoids in experimental studies. The present investigation was an attempt to evaluate the effect of Bisphenol A on testis and its amelioration by quercetin. Inbred Swiss strain male albino mice were orally administered with BPA (80, 120 and 240 mg/kg body weight/day) for 45 Days. On the completion of treatment, animals were sacrificed, testis was isolated and used for evaluation of energy metabolism (SDH and ATPase activity) and phosphatases activity (ACP, ALP). The results revealed that oral administration of BPA for 45 days caused significant dose-dependent reduction in activities of ATPase and SDH. However, ACP and ALP activities were significantly dose-dependent increased in BPA treated mice. Oral administration of Quercetin (30, 60 and 90 mg/kg body weight/day) along with high dose of BPA (240 mg/kg body weight/day) for 45 days caused significant amelioration in all biochemical parameters as compared to high dose of BPA treated group. Present study concludes that BPA causes reduction in energy metabolism and induces the activity of phosphatases. The effect was significant and dose-dependent. This amelioration in toxic effect of BPA might be due to antioxidant properties of quercetin.