PROTECTIVE EFFECTS OF COCCINIA GRANDIS LEAF EXTRACT: BEHAVIOURAL, ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND HISTOLOGICAL FEATURES OF DIABETIC NEUROPATHYAbstract
Present study aimed to evaluate the nociceptive, neuro-muscular coordination, electrophysiological, biochemical, and histological features of diabetic neuropathy in streptozotocin-induced diabetic rats and the protective effects of Coccinia grandis leaf methanolic extract. Coccinia grandis (200 mg/kg per day) was given to diabetic rats for 3 weeks. Metformin (150 mg/kg body weight) was used as standard reference drug. Coccinia grandis showed its protection against allodynia test. NCV was also attenuated by treatment of Coccinia. The significant decrease in AR shows its protection against diabetic complications. Histological alterations induced by diabetes in the sciatic nerve were restored with Coccinia grandis leaf extract treatment. These results suggest that Coccinia grandis has attenuated progression of diabetic neuropathy in STZ-induced diabetic rats.
B. Nagilla and K. P. Reddy *
Neurobiology lab, Department of Zoology, University College of Science, Osmania University, Hyderabad, Andhra Pradesh, India.
27 March 2014
21 May 2014
15 July 2014
01 October 2014