PROTECTIVE EFFICACY OF THE EXTRACT OF VOLVARIELLA VOLVACEA (BULLIARD EX FRIES) SINGER. AGAINST CARBONTETRACHLORIDE INDUCED HEPATIC INJURYAbstract
Carbon tetrachloride is a xenobiotic that produces hepatotoxicity. Aqueous extract Volvariella volvacea (500, 1000 mg/kg, p.o) showed significant hepatoprotective activity against carbontetrachloride induced hepatotoxicity in rats by normalizing the levels of serum AST, ALT, ALP, LDH and total bilirubin. The extract improved the activity of Catalase (CAT), Superoxide dismutase (SOD), and hepatic glutathione (GSH) content and depleted the lipid peroxidation levels in a dose dependent manner. Silymarin was used as the standard drug.
S.V. Kalava* and S.G. Menon
Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore-641029, Tamil Nadu, India
24 April, 2012
14 May, 2012
21 July, 2012
01 August, 2012