PROTEIN OXIDATION AND ANTIOXIDANT VITAMINS IN LEPROSYAbstract
Aims The presence of carbonyl groups in proteins has been used as a marker of ROS-mediated protein oxidation. The present work was undertaken to study the importance of endogenous antioxidants like Vitamin C and vitamin E in different types of leprosy patients.
Methods: Total 30 leprosy cases were studied. Patients were subjected to various tests like, serum protein carbonyl as an index of protein oxidation, while serum Vitamin C and Vitamin E levels as endogenous antioxidants.
Results: An increased level of protein carbonyl indicates oxidative stress .The levels of Vitamins C, E decreased significantly in leprosy.
Conclusions: Protein carbonyl can be used as sensitive indicator of oxidative stress in leprosy patients. Vitamin C and vitamin E can be supplemented along with anti-leprosy drugs to control the protein oxidation in leprosy patients.
Amit Asalkar, Sunita Girish* and Ranjana Naoley
Department of Biochemistry, B. J. Medical College, Pune, Maharashtra, India
07 June, 2011
12 August, 2011
27 October, 2011
01 November, 2011