PULSATILE DRUG DELIVERY OF CANDESARTAN CILEXETIL FOR CARDIOVASCULAR COMPLICATIONSAbstract
The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on changes in circadian rhythm. Time dependent pulsatile drug delivery consists of a core tablets containing Candesartan cilexetil with different excipients surrounded by coating materials. Coating materials consist of combinations of hydrophilic polymer as HPMC and hydrophobic polymer as ethyl cellulose in various combinations. Formulated tablets were evaluated for its micromeritics as well as post compression characteristics such as weight variation, hardness, friability, drug content uniformity and in vitro drug dissolution. The drug-excipients study was carried out by using FTIR. In vitro drug release studies were performed using pH 6.5 phosphate buffers for 8 hrs. Optimized formulation F10 was selected and tested for its accelerated stability which was found to be successful.