PULSATILE DRUG DELIVERY SYSTEMS: RECENT TECHNOLOGY
AbstractPulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single- and multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt with in the article. It summarizes the latest technological developments, formulation parameters, and release profiles of these systems. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arhythmic and anti-asthmatic. Current review article discussed the reasons for development of pulsatile drug delivery system, types of the disease in which pulsatile release is required, classification, advantages, limitation, and future aspects of pulsatile drug delivery system.
Article Information
9
960-969
702KB
2289
English
IJPSR
Abdul Sayeed*, Md. M. Hamed , Mohd. Rafiq and Nahid Ali
Assistant Professor, Mesco College of pharmacy Hyderabad
mohammedsayeed78@yahoo.in
25 November, 2012
30 December, 2012
14 February, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).960-69
01 March, 2013