QSAR STUDIES ON PPARγ AGONIST 2- ALKOXYDIHYDROCINNAMATES WHICH USE AS LEAD MOLECULE FOR THE SYNTHESIS OF NEW COMPOUNDS TO TREAT DIABETES AND NEUROLOGICAL DISORDERAbstract
Quantitative Structure-Activity Relationships (QSAR) is based on the assumption that the activity of a certain chemical compound is related to its structure. More precisely, this approach says that the activity or the property is related to the chemical structure through a certain mathematical algorithm or rule. Quantitative structure-activity relationship (QSAR) analysis used to understand the structural factors responsible for PPAR-γ agonistic activity of some 2- Alkoxydihydrocinnamates. Several pharmacophore-based models indicated the importance of steric, hydrophobic, and hydrogen bond acceptor groups to agonistic activity.
R. B. Tripathi *, M. Pande and G. Garg
Bioinformatics Lab, Department of Pharmacy, Mangalayatan University Beswan, Aligarh, Uttar Pradesh, India.
19 March 2014
28 May 2014
05 July 2014
01 October 2014