QUANTIFICATION OF FLUOROQUINOLONES FROM BULK, PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL MATRICES USING CHROMATOGRAPHIC TECHNIQUESAbstract
Fluoroquinolones are the most commonly prescribed synthetic antibacterial agents having improved pharmacokinetic properties and broad spectrum of activity. Due to their broad clinical activity they are the most promising drug for antibacterial chemotherapy. The current study focused on the application of similar chromatographic system for the analysis of a number of fluoroquinolones from bulk, pharmaceutical formulations and biological matrices. We have also summarized how a single chromatographic system can be used for the quantification of a number of fluoroquinoloes from their respective marketed formulation. A detailed systemic survey of the sample preparation techniques, the chromatographic conditions and detection of the respective fluoroquinolones has been presented in this study. In the course of this discussion the advantages and applicability of the high performance liquid chromatographic techniques are also examined.
Amit Kumar De, Ashok Kumar Bera and Biswajit Pal *
Department of Chemistry, St. Paul’s C. M. College, Kolkata, West Bangal, India.
25 August, 2015
01 October, 2015
13 November, 2015
01 February, 2016