QUANTITATIVE DETERMINATION OF DRUGS IN BULK AND TABLET FORM BY USING TETRACYANOETHYLENEAbstract
The present work narrates UV-Visible spectrophotometric methods have been developed for the determination of selected drugs viz., Lamotragine (LMT), Venlafaxine hydrochloride(VFX), Valacyclovir hydrochloride(VCL) and Ractopamine hydrochloride(RAC) in bulk and their pharmaceutical dosage forms by using Tetracyanoethylene (TCNE) as reagent. These methods have been developed based on the formation of charge transfer complexes of drugs as n-electron donor with TCNE as π-acceptor. The selected drugs were formed yellow color complex with TCNE in Acetonitrile and exhibited a doublet at 400 & 420nm. Under the optimized experimental conditions, Beer, s law is obeyed over the concentration ranges of 2.5-12.5µg/ml for the all selected drugs. The effect of polarity of solvents, reagent concentrations, LOQ, LOD, and effect of reaction time have been studied and optimized. These methods have been validated in terms of ICH guidelines and applied to the quantification of selected drugs in bulk and dosage forms
Bathini Srinivas, P. Yadagiriswamy and G. Venkateshwarlu*
Department of chemistry, University College of Science, Osmania University, Hyderabad, India.
19 November, 2015
14 January, 2016
03 April, 2016
01 May 2016