QUANTITATIVE PHYTOCHEMICAL PROFILE AND IN-VITRO ANTIOXIDANT POTENTIAL OF D5 CHOORANAM, AN ANTIDIABETIC SIDDHA FORMULATIONAbstract
D5 Chooranam is a classical Siddha formulation developed by Central Council for Research in Siddha, prescribed for the management of diabetes mellitus. The present work was carried out to assess phytochemical profile and also to explore the antioxidant potential of Siddha drug D5 Chooranam. The Phytochemical profile and antioxidant activity were evaluated in five different solvent extracts (Ethyl acetate, chloroform, ethanol, petroleum ether, and water) of D5 Chooranam. The phytochemical analysis of D5 Chooranam disclosed the existence of various phytochemicals in D5 Chooranam. The amount of phytochemicals present in D5 Chooranam also correlates with the various pharmacological activities as per its therapeutic indications. The considerable radical scavenging capacity of D5 Chooranam, particularly in its water extract, ethyl acetate extract, and fresh aqueous solution, is well justified by the results of all in-vitro antioxidant studies. These results reveal the beneficial effect of D5 Chooranam against oxidative stress associated disorders like diabetes mellitus and its complications. Hence it can be concluded that it may be due to the presence of vital phytochemicals in this exclusive novel blend of herbs and makes this formulation to be a virtuous choice for treatment of diabetes mellitus and its complications in Siddha clinical practice.
Gayathri Gunalan *, R. Rathinamala, S. Sugin Lal Jabaris, S. Suganya, A. Durga, S. Selvarajan, K. Kanakavalli and A. Rajendra Kumar
Siddha Regional Research Institute (Central Council for Research in Siddha, Kuyavarpalayam, Puducherry, India.
06 January 2023
25 April 2023
13 July 2023
01 September 2023