RAPID CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC DETERMINATION OF CITALOPRAM IN RELEVANCE TO PHARMACEUTICAL ANALYSIS
AbstractThis paper describes the study to measure the sensitivity and accuracy of two techniques, chromatography and spectrophotometry for the direct determination of citalopram in pharmaceutical formulations. Chromatography was performed on SE-30 column (1 m × 3 mm i.d) using Nitrogen as a carrier gas (flow rate of 40 ml/min), having retention time of 12.8 min. Calibration curve was found linear in the range of 200-400 µg/ml. LOD and LOQ values were found as 1.1726 µg/ml and 3.5535 µg/ml respectively and the recoveries were in the range of 98.36–100.07%. In spectrophotometry
Article Information
26
177-181
602KB
1098
English
IJPSR
R. S. Das*, Y. K. Agrawal and P. Prajapati
Research Scholar, Institute of Research and Development, Gujarat Forensic Sciences University, Sector- 18/A, Gandhinagar- 382007, Gujarat, India
06 September, 2011
25 December, 2011
29 December, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(1).177-81
1-January-2012
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