RECENT ADVANCEMENTS IN THE FORMULATION AND EVALUATION OF MICROPARTICLES AND ITS APPLICATION

Introduction: The micro particles and development in the area of micro particles analysis are discussed in this article. Areas Covered: Micro particles are a unique drug carrier method that provides an effective therapeutic alternative to single-unit dose forms that are either traditional or rapid release. Micro particles are produced by filling them with firm gelatin or compressing them immediately. When compared to traditional dosage forms, micro particles manufactured using various types of technologies vary their performance and administration of the dosage form. Micro particles have been tested using in-vitro release techniques like dialysis membrane sacs, and USP equipment IV. According to comparisons of these techniques, USP apparatus IV is the preferred method right now. Accelerated in-vitro release assays were created to reduce the amount of time required for quality control testing. To reduce the necessity for in-vivo performance analysis, in-vitro and in-vivo correlation using real-time and accelerated release data have been produced. Storage stability studies have been carried out to see how different environmental conditions affect microsphere quality over the course of the product’s life span (t90). New tests like the in-vitro wash off test and floating test have been introduced, as have characterization approaches for various physico-chemical characteristics such drug content, thermal properties and particle size.