RECENT ADVANCES AND DIFFERENT APPLICATIONS OF PETASIS-BORON MANNICH REACTIONAbstract
The Petasis boron–Mannich process, also referred to as the Petasis reaction, combines boronic acid, an amine, and a carbonyl derivative in a multi component coupling process. Recent progress on petasis reaction is discussed in this review. The various merits of petasis reaction over the other multi-component coupling reactions are explain here. Noncanonical substrates are used to explore the expansion of a variety of petasis reactions, including two–component, three–component, and four–component reactions, processes, and products. In this review, Microwave–assisted reactions are also explored. The optimal conditions are involved in the microwave heating process. The conditions are successfully applied for petasis reaction. Different solvents are used in petasis boron-mannich reactions, such as glycerol and water. Both solvents are suitable for the reaction and give favorable yield. The reactivity along with numerous synthetic applications of the Petasis reaction are given in this review. The natural product synthesis are given by Petasis boron-Mannich reaction in which loline alkaloid and sialic acid synthesis are given.
K. Daware *, S. Jadhav, K. Varma, K. Valve, S. Shinde, V. Pardesi, A. Shelke and T. Lokhande
Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidyamandir’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.
23 February 2022
29 April 2022
04 May 2022
01 November 2022