RECENT APPORACHES IN BILAYERED TECHNOLOGY: REVIEWAbstract
Bilayered tablet is an important pharmaceutical technology for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, to separate incompatible substances and also formulating sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Now days the pharmaceutical companies are currently developing bi-layer tablets due to variety of reasons such as patent extension, therapeutic benefit and a marketing strategy. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains about different techniques of bilayered tablet preparation the development and production of bilayered tablets needs to be carried out on purpose built tablet presses to overcome common bilayered problems such as layer separation, insufficient hardness, and inaccurate individual layer weight control, cross-contamination between the layers, reduced yield and evaluation of bilayered tablets.
Parnapalli Malathi* and Arshad Bashir Khan
Department of Pharmaceutics, Krupanidhi College of Pharmacy, Sarjapura main road, Carmelaram post, Bangalore-560 035, Karnataka, India
31 August, 2012
16 October, 2012
24 November, 2012
01 December, 2012