RECENT APPROACHES IN SELF EMULSIFYING DRUG DELIVERY SYSTEMAbstract
Self emulsifying is a topic of current interest for overcoming the formulation difficulties of drugs with poor aqueous solubility. SEDDS are isotropic mixture of oil, surfactant and co-surfactant with a unique ability to form fine oil-in-water (o/w) emulsions or micro emulsions upon mild agitation in the gastrointestinal tract which present the drug in a solubilized form, and the small size of formed droplet provides a large interfacial surface area for drug absorption. It is a promising strategy to improve the rate and extent of oral absorption. The SEDDS were characterized for robustness to dilution, globule size, polydispersity index and zeta potential.
Khushboo Singh*, Monika Sharma, Kamal Gandhi and Asha
Ram Gopal College of Pharmacy, Sultanpur, Tehsil-Farrukhnagar, Distt. Gurgaon, 122001, Haryana, India
29 May, 2012
14 October, 2012
29 October, 2012