RECENT DEVELOPMENT AND ACHIEVEMENTS IN SOLUBILITY AND DISSOLUTION ENHANCEMENT OF ITRACONAZOLE: A REVIEWAbstract
A drug should be available in accessible in disintegrated state before producing its therapeutic effect however; in current market more than 40%, drugs are poorly soluble in water. In view of their low aqueous solubility, those new chemical entities fail to reach market in spite of revealing potential pharmacodynamics activities. Poorly aqueous soluble drugs are connected with moderate drug absorption leading inevitably to insufficient and variable bioavailability. Consequently, different methodologies have been grasped for solubility and dissolution enhancement of poorly water-soluble drugs thus bioavailability. Solubility assumes a paramount part in attaining the desired plasma drug concentration. In this review article, different techniques like solid dispersion using hot stage extrusion, freeze-drying, spray drying, and hot melt extrusion also nano suspensions, dried emulsions were discussed for solubility and dissolution rate improvement of BCS class II antifungal drug Itraconazole. Amongst various method described in this review, solid dispersion was found to be most preferred technique by researcher as it provide ease in preparation and efficiency in terms of resolving the solubility and dissolution problems associated with Itraconazole.
Jaywant N. Pawar*, Tarique M. Ali, Kailash K. Moravkar, Rahul K. Patole , Divakar R. Jaiswar and Purnima D. Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai 400019, Maharashtra, India
15 February, 2014
04 April, 2014
17 June, 2014
01 August, 2014