RECUPERATION OF DIABETES INDUCED OXIDATIVE DAMAGE IN LIVER BY TREATMENT WITH CURCUMIN IN STZ INDUCED DIABETIC RATSAbstract
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and increase in malondialdehyde (MDA) was observed in the diabetic rats. Decreased activities of antioxidant enzymes and body weights in diabetic rats were augmented on the oral administration of Curcumin. Moreover, Curcumin administration depleted the MDA level, which was earlier increased in the diabetic rats. These results suggest that Curcumin exhibits a hepatoprotective effect by accelerating hepatic anti-oxidant defense mechanisms and downregulating the MDA levels to the normal levels in the diabetic rats. Thus, Curcumin may be used as a therapeutic agent in preventing complications in diabetic patients.
S. N. Shameer * and D. Sudhakar
Department of Zoology & Biotechnology SGS Arts College (TTD) Tirupati, Andhra Pradesh, India.
28 November 2019
06 February 2020
22 February 2020
01 December 2020