RESEALED ERYTHROCYTES: AN ADVANCED REVIEWAbstract
Erythrocytes are the most abundant cells in the human body (~5.4 million cells/mm3 blood in a healthy male and ~ 4.8 million cells/mm3 blood in a healthy female) having potential carrier capabilities for the delivery of drugs and drug loaded microspheres. Drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers. Encouraging the use of erythrocytes in drug delivery include various advantages like as remarkable degree of biocompatibility, Complete biodegradability, lack of toxic product, controllable life-span, decreasing drug side effects etc. So many drugs like aspirin, steroid, cancer drug which having many side effects are reduce by resealed erythrocyte. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this review we discuss about Resealing of erythrocytes, various techniques of drug loading and it’s applications in various fields of human and veterinary medicine.
S.R. Kolhe* and S. Sontakke
Progressive Education Society’s Modern College of Pharmacy (for Ladies), Moshi, Pune- 412105, Maharashtra, India
18 August, 2012
03 October, 2012
20 November, 2012
01 December, 2012