REVIEW OF ANALYTICAL METHODS FOR IDENTIFICATION AND QUANTIFICATION OF ZOLMITRIPTANAbstract
Zolmitriptan is a selective serotonin receptor agonist of 1B and 1D receptors belonging to the triptan class. Zolmitriptan binds to the serotonin (5-HT) 1B receptors, receptor binding leads to inhibition of nociceptive transmission, constriction of cranial vessels, and reduction of vessel pulsation, thereby providing relief of migraine headaches, as Zolmitriptan holds great importance in migraine headaches, it is necessary to compile the various analytical methods that have been reported in the literature for its analysis in pharmaceuticals or bulk products and in bioanalysis. Analytical techniques are used for pharmaceutical analysis and therapeutic drug monitoring to study bioavailability and bioequivalence. Most of the analytical methods reported for its determination are the ones that utilize HPLC and other hyphenated techniques like LC-MS, UPLC-MS, LC-MS/MS. Therefore, the present review provides a summary of the HPLC-based methods used in the determination and quantification of Zolmitriptan in different matrices since the time of its discovery.
S. Venkata Sai Kumar *, K. Srinivasa Rao and R. N. Bhushan
Department of Pharmaceutical Analysis and Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, Andhra Pradesh, India.
29 January 2021
09 June 2021
11 June 2021
01 February 2022