REVIEW ON ADVANCES IN COLON TARGETED DRUG DELIVERY SYSTEMAbstract
The colon is the terminal part of the GIT which has gained in recent years as a potential site for delivery of various novel therapeutic drugs, i.e. peptides. However, colon is rich in microflora which can be used to target the drug release in the colon. Colon is a site where both local and systemic drug delivery can take place. Local delivery allows the topical treatment of inflammatory bowel disease. If drug can be targeted directly into the colon, treatment can become more effective and side effects can be minimized. These systemic side effects can be minimized by primary approaches for CDDS (Colon specific drug delivery) namely prodrugs, pH and time dependent systems and microbially triggered system which gained limited success and have limitations as compared with recently new CDDS namely pressure controlled colon delivery capsules (PCDCS), CODESTM (Novel colon targeted delivery system) osmotic controlled drug delivery system, Pulsincap system, time clock system, chronotropic system. This review is to understand the pharmaceutical approaches to colon targeted drug delivery systems for better therapeutic action without compromising on drug degradation (or) its low bioavailability.
Sunena Sethi, SL Harikumar* and Nirmala
Rayat & Bahra Institute of Pharmacy, Sahauran, Kharar, Dist. Mohali -140104, Chandigarh, India
16 May, 2012
14 June, 2012
17 August, 2012
01 September, 2012