REVIEW ON MICROSPONGE LEADING MICROPOROUS PARTICULATE TECHNOLOGY WITH CONTROLLED RELEASE, IMPROVE STABILITY TO PROVIDE OPTIMUM SKIN DISORDERS MANAGEMENT ENVIRONMENT FOR THERAPEUTIC APPLICATIONAbstract
Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduce side effects. Microsponges are polymeric sponges that consist of interconnecting voids with a non-flexible structure with a porous surface. Microsponge delivery technique provides extended product stability, enhanced safety, enhanced formulation flexibility, enhanced product efficacy, enhanced aesthetic appeal with reduced side effects. Therefore, this review provides an overview of microsponge technology with its methodology, mechanism, programmable release, and characterization of the microsponge delivery system. Review compiled recent data regarding marketed formulation, their applications, and the list of patents. This review also contains validation, stability guidelines, and examples of drug release profiles from microsponges. Microsponges are frequently used for topical use but recently used for oral use.
N. Tomar, N. Pawar * and K. Bahmani
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, India.
28 January 2020
29 March 2020
31 March 2020
01 November 2020