REVIEW ON NON-VIRAL DELIVERY SYSTEMS FOR siRNA
AbstractThe emergence of RNAi, has found new horizons in siRNA as drug molecule. This technology offers a great promise in the achieving efficient treatment. There is a demand for designing efficient siRNA delivery systems/ vehicles that can achieve targeted delivery and replicate the invitro success. The siRNA delivery system selection is based on target cell type. The siRNA delivery systems are categorized as viral and non-viral delivery systems. Non-viral delivery system includes liposomes; polymers; peptides etc. are the widely studied delivery systems for siRNA. Non-viral delivery systems have advantages of control over functionality and industrial scalability. Liposomes were one of the first studied siRNA non-viral delivery systems which with time have evolved on account of modifications on certain attributes like surface charge, surface tagging, composition etc. Peptides and Polymers are the recent addition to the non-viral siRNA delivery vehicles on account of biocompatibility factor. This review clubs the non-viral siRNA delivery systems which have attracted research and have shown efficiency in the clinical trials.
Article Information
1
294-301
377
1112
English
IJPSR
Vikas Verma* and Preeti Sangave
Department of Pharmaceutical Chemistry and Pharmaceutical Biotechnology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management (SPPSPTM), SVKM’s NMIMS (Deemed to be University), V.L. Mehta Road, Vile Parle (W), Mumbai – 400 056, Maharashtra, India
vikasvma@gmail.com
07 September, 2013
30 October, 2013
16 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).294-01
01 February, 2014
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