REVIEW ON THE IMPACT OF DIABETES ON KIDNEY DISEASE

Diabetic kidney disease (DKD) is the main reason for end-stage renal disease on a global scale. About 40% of developing diabetic kidney disease, which is the most common cause of chronic kidney diseases worldwide. Although ESRD may be the most complication of diabetics, as a result of their physical health and any co-morbidities they may have, such as obesity, hypertension, dyslipidemia, intrarenal vascular disease, renal ischemia, or age-related nephron loss, One-third of people with type 1 diabetes and at least half of people with type 2 diabetes will eventually develop renal dysfunction. CKD is present and is severe. Glomerular hyperfiltration, falling GFR, and finally, ESRD are parts of the diabetic kidney disease natural history. Diabetes-related complications can lead to diabetic kidney disease.  Disturbances in glucose metabolism, hypertension, dyslipidemia, develop kidney disease. Controlling blood sugar levels, blood pressure, and renin-angiotensin-aldosterone system blockage are all part of intensive therapy for diabetic patients; For diabetic kidney damage to be postponed or prevented, glycemic management is crucial. Several glucose-lowering drugs are on the market, but only a small percentage of them can be used safely in chronic kidney disease. The risk of kidney failure and cardiovascular events is significantly increased by diabetic renal disease, which has a significant global disease burden. There is still with current treatments. In order to find treatments that can halt the progression and lower risks, it is crucial to better understand the molecular pathways behind diabetic kidney disease. Which is subsequently accompanied by various metabolic, hemodynamic and inflammatory markers.