REVOLUTIONIZING MEDICINE: THE FUTURE BUCCAL FILM-BASED DRUG DELIVERY SYSTEM

This study explores buccal drug delivery as an alternative to traditional oral medications, emphasizing its advantages in bioavailability, drug stability, and therapeutic efficacy. Key formulation factors, including swelling index, drug content, folding endurance, and surface pH, are evaluated alongside various production techniques such as solvent casting, hot-melt extrusion, and freeze-drying. The study also examines emerging technologies like co-crystallization, lipid-based formulations, solid dispersion technology, 3D printing, and AI-driven formulation design, which enhance drug stability and solubility. Findings indicate that buccal films improve bioavailability by bypassing first-pass metabolism while advanced formulation techniques enhance the solubility of poorly soluble drugs. However, challenges such as formulation stability and drug load capacity necessitate further research into nanotechnology, smart polymers, and multilayer films to optimize controlled drug release and permeability. Buccal films offer a promising drug delivery platform for various therapeutic applications, including cancer treatment, cardiovascular diseases, smoking cessation, hormone therapy, and pain management. Future advancements in smart materials and nanotechnology can further enhance therapeutic outcomes, patient compliance, and drug delivery efficiency, positioning buccal films as a transformative approach in modern medicine.