ROLE OF ADHESIVES IN TRANSDERMAL DRUG DELIVERY: A REVIEWAbstract
Transdermal drug delivery systems (TDDS) also commonly known as “patches” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. The therapeutic performance of a transdermal delivery system (TDS) can be affected by the quality of contact between the patch and the skin. The adhesion of the TDS to the skin is obtained by using pressure-sensitive adhesives (PSAs), which are defined as adhesives capable of bonding to surfaces with the application of light pressure. This article provides an overview of types of transdermal, the anatomical considerations and role of adhesion, the possible adhesion failure modes and how adhesion can be measured. Several in vitro techniques have been used to monitor adhesive performance such as peel adhesion, tack and shear strength. This article provides a frame work for further discussion and scientific work to improve transdermal adhesive performance.
Deepthi Venna and Arshad Bashir Khan*
Department of Pharmaceutics, Krupanidhi College of Pharmacy, Sarjapura Main Road, Carmelaram post, Bangalore-560 035, Karnataka, India
29 June, 2012
24 July, 2012
13 September, 2012