ROLE OF CHITOSAN AND EUDRAGIT IN POLYMER – BASED EXTENDED RELEASE MATRIX TABLETS – A REVIEWAbstract
The present article describes the recent role of polymers as carriers for delivery of drug at target site to extending its release. These polymers are widely used in delivery due to their inherent characteristics such as biocompatibility, biodegradability. Chitosan and Eudragit are choice of drug in extended release matrix tablets. Chitosan is an amino polysaccharide polymer which is biodegradable, biocompatibility and nontoxic nature. Due to its cationic nature, Chitosan form complex with anions like Eudragit giving rise to polyelectrolyte complexes. Chitosan enhances the dissolution of poor soluble drugs. Similarly Eudragit polymers are also copolymers derived from esters of acrylic and methacrylic acid and have large number of applications in extending drug delivery. This article reviewed the role of Chitosan and Eudragit in controlled release drug formulations. Also, the article included role, property and uses of Chitosan and Eudragit and their use in different drug delivery system for various therapeutic applications.
A. Prusty* and B. K. Gupta
Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri, Odisha, India.
09 April, 2017
07 June, 2017
29 June, 2017
01 December, 2017