ROLE OF MELT EXTRUSION IN THE ENHANCEMENT OF BIOAVAILABILITYAbstract
Starting from plastic industry, today melt extrusion has found its place in the array of pharmaceutical manufacturing processes. Melt extrusion processes are currently applied in the pharmaceutical field for the formulation of variety of dosage forms such as granules, pellets, tablets, implants, transdermal systems & ophthalmic inserts. This technology represents an efficient pathway for increasing the solubility of poorly soluble drugs. The process forms a solid dispersion where the drug is presented in an amorphous & molecularly dispersed state in a carrier. This leads to an increase in solubility, as no lattice energy has to be overcome during dissolution. Melt extrusion is considered to be an efficient technology in the field of formulation of solid dispersions to improve bioavailability with particular advantages over solvent processes. This article highlights on the technology of Hot Melt Extrusion (HME).
Sahil Bansode* and S. S. Poddar
Department of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuff Parade, Colaba, Mumbai- 400 005, Maharashtra, India
30 July, 2012
28 August, 2012
26 October, 2012