ROLE OF N-ACETYLCYSTEINE IN RESCUE OF MICE HEARTAbstract
An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in the treatment of cardiovascular diseases. N-acetylcysteine is an antioxidant which confers its protective effect by minimizing oxidative stress and oxidative stress associated problems. A search using the Pub Med database was conducted using the keywords N-acetylcysteine and mice heart. All research articles related to the use of N-acetylcysteine in protection of mice heart were discussed. A total of 93 articles were identified during this broad search while 30 articles were included for review recommending the N-acetylcysteine for protection of heart. This review proved that N-acetylcysteine has a positive role in management of multiple heart diseases.
Fatima Ali*, Nadia Wajid, Hina Yousaf and Maria Anwer
Institute of Biotechnology and Biochemistry, The University of Lahore, Lahore, Pakistan
18 November, 2013
25 February, 2014
24 March, 2014