ROLE OF SERUM BILIRUBIN IN CLINICALLY ADMITTED PATIENTS TO PREVENT THE RISK OF CARDIAC DISEASESAbstract
Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation. Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of CVD. Bilirubin exerts a strong antioxidant effects at physiological plasma concentrations against lipid oxidation in blood artery.
Methodology: Parameters were measured on a fully automated analyzer using standard reagent kits in a retrospective study involving 100 male Indian subjects between 35 to 55 years of age.
Results: Serum total bilirubin was correlated positively with serum high density lipoprotein (HDL), while it was negatively correlated with glycosylated hemoglobin (HbA1c), there were no statically significance present between serum total cholesterol and serum triglyceride in hospitalized patients, not in healthy subjects.
Conclusions: we were concluded that, the serum total bilirubin concentration will be an independent cardiovascular risk factor such as lipid profile.
Neha Sharma*, Sadhna Sood and Girdhar Gopal Kaushik
Department of Biochemistry, SRMS-Institute of Medical Sciences, Bareilly, Uttar Pradesh, India
03 October, 2013
13 December, 2013
27 February, 2014