ROLE OF SESAMUM ALATUM L. ON NEPHROPATHY IN DIABETIC RATS

Background: Type 2 Diabetes is a metabolic disorder, characterized by chronic hyperglycemia.  It results from insulin resistance, a condition in which the body cells fail to use insulin properly. In Ayurveda Sesamum alatum L. (Pedaliaceae) has been used for the treatment of Diabetes. In this study, the antidiabetic activity of the Methanolic leaf extract of S. alatum was investigated, and the renal protective activity of the extract was also evaluated in diabetic rats.

Materials & Methods: Antidiabetic activity of the Methanolic Leaf Extract of Sesamum alatum (MESA) was evaluated in the Streptozotocin (65mg/kg) induced Male albino rats. Blood was collected from the Retro orbital plexus of rats’ before and after the administration of MESA. Activity of 300 and 500 mg/kg doses of MESA were evaluated for a period of 30days. Urine samples were collected and analyzed for Albumin, BUN, Creatinine and Lipid parameters. In addition, Kidney MDA levels, Antioxidant enzymes (SOD, CAT) and Non-Enzymatic (GSH) levels were measured.

Results: Dose-dependent reduction in blood glucose levels were observed in treated group & it can be comparable with that of Standard drug, Glibenclamide. Significant Renoprotective activity was observed in the MESA treated group. MESA (500mg/kg) has shown the antidiabetic activity by improving the levels of GSH, SOD, CAT and has decreased the levels of MDA in kidney. And the other Blood and urine parameters were normalized in treated groups.

Conclusion: Present study clearly supported significant Antidiabetic Renoprotective activity of Sesamum alatum. Further investigation is needed to determine the exact Phytoconstituent(s) which are responsible for the Antidiabetic activity