ROLE OF TERPENOIDS AS HEPATOPROTECTIVE

The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwide, approximately 2 million deaths, 1million due to complications of cirrhosis, and 1 million due to viral hepatitis and hepatocellular carcinoma have been found every year. Now a day number of synthetic medicine available in the market for the treatment of liver disorders, but they have lots of side effects. So, the developed countries recently give their interest in herbal drugs. Many Ayurveda herbs, such as Andrographis, Punarnava, kokum, and soon have a long history of traditional uses in revitalizing the liver and treating liver dysfunction from the various literature survey this can be concluded that the plant containing a high amount of terpenoids possess good hepatoprotective effect. There are some plants enriched with a high amount of terpenoids such as Andrographolide, Podophyllum hexanderum, Origanum vulgare, and soon are very potential for hepatic disorders. The aim of this review is to enlighten the number of plants containing terpenoids and terpenoids for their hepatoprotective activity.