ROLE OF VITAMIN D IN CARDIOMETABOLIC DISORDERS – A REVIEW BASED ON PATHOPHYSIOLOGY AND CLINICAL EVIDENCESAbstract
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic disorders are a major health problem in developing as well as in developed countries. It has been observed in the previously reported clinical studies that deficiency of vitamin D is a highly prevalent risk factor in the patients with cardiometabolic disorders and it has been suggested that deficiency of vitamin D has a crucial role in the pathogenesis of cardiometabolic disorders. Aim: To reveal the role of vitamin D deficiency in cardiometabolic disorders and the opportunity of vitamin D supplementation as vital therapy in cardiometabolic disorders. Methods: We performed a systematic review based on available literature of vitamin D deficiency in cardiometabolic disorders using PubMed, Google Scholar, Science Direct, and Willey online library databases up to November 2020. Conclusion: Vitamin D deficiency has a significant role in the pathogenesis of cardiometabolic disorders. Therefore, vitamin D supplementation may help in mitigating cardiometabolic disorders. However, there is a need to generate large controlled clinical trials with an appropriate sample size.