ROLE OF VITAMINS ON LEAD INDUCED ALTERATIONS IN DEVELOPING TESTIS OF SWISS MICEAbstract
Aim: The aim of the present study was to evaluate lead toxicity on the male reproductive system during developing period of neonates.
Methods: Histopathological alterations were observed in testis of neonates on PND 1 and PND 21. Lead acetate was administered via oral gavaging at 320 mg/kg BW to pregnant Swiss mice from 10th day of gestation upto 21st day of lactation. OralExposure of 160 mg/kg BW vitamin C (ascorbic acid) and 130 mg/kg BW vitamin E (tocopherol acetate) was given from 10th day of gestation upto 21st day of lactation.
Result: Oral supplementation of antioxidants vitamin C and E with lead slightly recovered these adverse effects and retained normal function but independently they also induced obstruction in development of testis.
Conclusion: We can conclude from our findings that lead acetate administrated during gestation and lactation adversely affects developing testis. Supplementation of high doses of vitamins during gestation and lactation are not beneficial because they also generate some alterations in developing gonads.
Ragini Sharma and Umesh Garu
Environmental and Developmental Toxicology Research Laboratory, Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India
14 June, 2013
02 August, 2013
23 October, 2013
01 November, 2013