RUBBER SEED CLEANSING OIL FORMULATION AND ITS EFFICACY OF MAKEUP REMOVERAbstract
The objective of this study was to determine the safety of rubber seed oil in terms of toxicity, residual solvent and to develop rubber seed cleansing oil as a makeup remover. The cytotoxicity of rubber seed was determined on human fibroblast cell. It was not cytotoxic to human fibroblast cell at >1000 µg/ml. Rubber seed oil was further examined for the presence of linamarin toxin and determining the solvent residual. FTIR spectrum revealed that there was no presence of cyanide peak and, n-hexane residual was 60.35 ± 1.12 ppm. Based on these results, it was suggested that rubber seed oil was safe to be developed as a product for cosmetic applications. The rubber seed cleansing oil was formulated in various compositions of rubber seed oil (5, 10 and 15%) combined with sorbeth-30 tetraoleate (HLB 11.5) and sorbitan sesquioleate (HLB 3.7) and the ratio of surfactant was 10, 15 and 20% respectively. The most suitable formulation with good physical properties was obtained from 5% of rubber seed oil, and 15% of surfactant. The makeup removal efficacy of rubber seed cleansing oil was 89.89 ± 2.75% against the liquid foundation.
P. Raknam, S. Pinsuwan and T. Amnuaikit *
Department of Pharmaceutical Technology and Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla, Thailand.
05 April 2019
05 July 2019
19 July 2019
01 January 2020