SAGA OF GASTRORETENTIVE DRUG DELIVERY SYSTEM: EMERGING CONCEPTS, RECENT ADVANCES AND TECHNOLOGICAL PROGRESSAbstract
Oral controlled release and site-specific drug delivery systems have gained interest in the pharmaceutical industry to improve the treatment of certain critical medications. To overcome physiological barriers, such as short stomach resident lengths and variable gastric emptying periods, the idea of a novel drug delivery mechanism evolved. To improve the bioavailability of drugs with narrow therapeutic windows, delay the onset of drug elimination from the body, and increase patient compliance, one of these novel approaches is the gastroretentive drug delivery system (GRDDS), which is implanted in the upper part of the gastrointestinal tract. This investigation discusses the GRDDS, factors associated with the GRDDS, the advantages and disadvantages of the GRDDS, alternative approaches to the GRDDS, and different polymers used for gastroprotection. A great deal of work is being put into developing several GRDDS types at the moment. Because of this, pharmacotherapies of all types stand to benefit from their growing prominence shortly.
Tushar Kishor Sambre *, Tarak Mehta and Tanvi Tushar Sambre
Yashodhara Bajaj College of Pharmacy, Chandrapur, Maharashtra, India.
25 July 2022
18 October 2022
04 November 2022
01 May 2022