SALIVARY ENZYMES AS BIOMARKERS FOR TREATMENT OF PATIENTS WITH PERIODONTITIS: A FOLLOW-UP STUDY

Effective treatment depends on early and successful disease detection. A timely, cost-effective diagnostic method is the principal part of the treatment plan. The invention of saliva-based microbial, immunologic, and molecular biomarkers offers novel opportunities to bypass the shortcomings of other methods by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Periodontitis is a common oral disease characterized by inflammation, connective tissue breakdown & alveolar bone loss. One of the important features of inflammation is enzymes from different oral tissue. The aim of the study is to detect salivary & serum enzyme levels in patients with periodontitis. The aim of the present study was to evaluate salivary enzyme levels in patients with periodontitis. Our present study aims to assay the salivary Aspartate & Alanine Aminotransferase, Alkaline & Acid Phosphates levels in a patient with generalized periodontitis before & after treatment. Material & Method: A total of 212 participants, males & females, were selected. Group A comprised 106 healthy adults, and Group B 106 patients generalized periodontitis test group. All individuals assessed by the clinical parameters of patients within group B underwent periodontal treatment for 2 weeks. The salivary samples were collected at baseline from all groups (before done by applying student’s ‘t’ & ‘z’ test. Results: Aspartate & Alanine Aminotransferase & Alkaline & Acid Phosphates increased significantly in saliva before treatment in relation to healthy controls. After periodontal treatment, salivary enzymes (p=0.0001) significantly decreased. Conclusion: After treatment enzymes could prove patients had low aspartate & alanine aminotransferase & Alkaline & Acid Phosphates clinically indicates salivary enzymes act as biomarkers and could be used as diagnostic tool.