SCOPE OF AZETIDINONE HYBRIDS FOR DIVERSE PHARMACOLOGICAL ACTIVITIES; A REVIEW

Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alarming increase in the bacterial resistance to the β-lactam nucleus may be due to irrational usage, which unfortunately led to less therapeutic usage. Hence new hybrids of Azetidinones with other drugs containing different heterocyclic rings found to possess broad-spectrum efficacy against various types of bacteria with β-lactamase inhibition to find great scope for future needs. This concept of hybrid molecules of different heterocyclic drugs would be a cost-effective and time-saving experiment in the process of drug discovery and development. In today’s world of diseases and expensive drugs which are not affordable for countries like India, this attempt would be noon. Hence this review is an attempt to focus on the possible hybrid molecules of Azetidinones with other heterocyclic drugs for various diseases.