SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF VILAZODONE IN RODENTSAbstract
The analgesic activity of vilazodone in albino rats and mice was compared with the standard drug pentazocine and diclofenac, and its anti-inflammatory activity in albino rats was compared with the standard drug indomethacin. The doses of vilazodone used were 1.8mg/kg and 3.6mg/kg in albino rats and 2.6mg/kg and 5.2 mg/kg in albino mice, and the methods to screen analgesic activities were eddy’s hot plate method, tail flick method using radiant heat and acetic acid induced writhing method and formalin-induced peritonitis was used to screen anti-inflammatory activity. The data was analyzed statistically and results were expressed as numbers and percentages. For vilazodone dose of 1.8mg/kg and 3.6mg/kg using eddy’s hot plate method mean reaction time were 6.50± 0.288 and 5.70± 0.285, in tail flick method 6.50±0.288 and 6.45± 0.521. In the writhing method at a dose of 2.6mg/kg and 5.2 mg/kg in albino mice vilazodone showed 30.33±1.15 and 28.16±0.98 analgesic activity compared to control. In formalin induced peritonitis vilazodone 1.8mg/kg and 3.6mg/kg showed 2.2±0.13 and 1.86±0.05 anti-inflammatory activity when compared to control. Statistically significant results were obtained with a higher dose in hot plate and tail flick method and with low dose in writhing method when compared to the standard. Vilazodone, compared to standard in formalin-induced peritonitis, has shown statistically significant results in both doses. Vilazodone has shown significant analgesic and anti-inflammatory activities.
L. R. Divyashree, Aruna Bhushan * and Pankaj Kumar Masare
Department of Pharmacology, JGMM Medical College, Hubballi, Karnataka, India.
21 August 2022
04 November 2022
17 November 2022
01 May 2023