SCREENING OF NATURAL PIGMENTS FROM SEAWEED KAPPAPHYCUS ALVAREZII AND ITS EFFICACY IN PHARMACEUTICAL PRODUCTSAbstract
This paper focused on research on seaweed contains good nutritional source of protein, carbohydrate, pigments, vitamins, and antioxidants and has low lipid content. The source of natural substances has considered more efficient bio-molecules in building immunity and improving resistance to cancer development, prevent infections were analyzed. Classical biochemical methods were applied for extraction of pigments and other related components from red algae; subsequently, quantities of each substance were determined and discussed its potential properties. Considerable attention has been focused on pigments-based biomaterials attributes antioxidant, antitumor, and immune-modulating properties due to their multi-functional qualities. The fresh solvent extracts of K. alvarezii was found to be rich in total anthocyanin 17 mg/g.f.wt content and vitamin C 21 mg/g.f.wt. Furthermore, the efficient combination treatment with anthocyanin plus vitamin C resulted in better therapeutic efficacy than carboplatin drug against Dalton’s lymphoma tumor. The tumor cell growth was arrested due to the administration of anthocyanin plus vitamin C (500µg/kg body wt. i.p) to tumor-bearing mice; thereby the efficiency of biomolecules was confirmed. The western blot analysis explained GST expression appears to have antitumor potential to treat ascites Dalton’s lymphoma in the animal model. Kappaphycus alvarezii is considered a source of unique natural products applied in pharmaceutical formulations and makes them suitable biomaterials for drug delivery, and its anti-tumor properties might help develop functional pharmaceutical products in the future.
R. Nithyaa and G. Renuga *
Department of Biotechnology, Sri Adi Chunchanagiri Women’s College, Cumbum, Theni (Dt.), Affiliated to Mother Teresa Women’s University, Kodaikanal, Tamil Nadu, India.
21 April 2021
14 June 2021
05 January 2022
01 February 2022