SCREENING OF PLANTS FOR ANTI DERMATOPHYTE ACTIVITYAbstract
Mycotic infections of skin are caused by dermatophytes. Screening of plants for anti dermatophyte activity was carried out based on the literature search done. Native plants of Maharashtra (India) were screened for anti dermatophyte activity. Various plant parts from different regions were collected and then extracted with three different solvents viz. alcohol, hydro-alcohol and aqueous. The obtained extracts were subjected for anti dermatophyte activity using agar-well diffusion technique. Three different concentrations of extract were checked for activity. Two species of dermatophytes, viz. – Trichophyton and Microsporum were used in the screening assay. Out of the twenty-eight plants screened by agar diffusion method, seven were found to be active with different activity profile. Methanol extract was the most active extract. Pterospermum suberifolium, Trachyspermum ammi, Peltaphorum pterocarpum, Ixora coccinia, Persicaria glabra, Terminallia elliptica and Cicca acida showed activity at different concentrations against the two species of dermatophytes. The data obtained can be used for further studying the anti dermatophyte potential of active plants.
V.S. Chauhan, A. Suthar, V. Naik and K. Salkar*
Piramal HealthCare Limited, Nirlon Complex, 1A, 1B, 1C, Off Western Express Highway, Goregaon (east), Mumbai-400063, Maharashtra, India
27 January, 2012
13 March, 2012
28 April, 2012
01 May, 2012