SELF-ASSEMBLED BIODEGRADABLE POLYMERIC NANOPARTICLES WITH IMPROVED SOLUBILITY OF CARVEDILOL: PREPARATION, CHARACTERISATION AND IN VITRO RELEASE KINETICSAbstract
Nanoparticles (NPs) have been extensively studied during the past few decades due to their well-recognised applicability. Thus, the present study was aimed to fabricate Carvedilol (CVD) a β-adrenoceptor antagonist, as NPs aiming towards the optimal physicochemical characteristics and improved solubility. The prepared NPs demonstrated a linear increase in the mean particle size from253 ± 19 to 598 ± 21 nm and entrapment efficiency (%EE) from 58.6% to 91.1%, when drug-to-polymer mass ratio was increased from 1:1 to 1:5. In vitro release studies showed significant variation in the rate and extent of CVD release from polymeric matrix at various pHs of release media (pH 1.2, pH 6.8 and distilled water) and drug-to-polymer mass ratios. The present study highlighted the optimal formulation conditions to fabricate CVD-loaded NPs with best physicochemical characteristics, improved solubility of incorporated drug and explored the prospects of manipulation and optimisation of the NPs for intended applications.
S. Khan , W. Ali, N. Ur Rahman, S. Md. Mukarram Shah, J. Khan, S. Md. Hassan Shah, Z. Hussain *
Department of Pharmaceutics , Faculty of Pharmacy, Universiti Teknologi MARA, PuncakAlam Campus, Selangor, Malaysia
22 May, 2016
02 September, 2016
23 September, 2016
01 October, 2016