SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEWAbstract
Solubility of orally administered drug is major challenge of pharmaceutical industry as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to their poor dissolution and low bioavailability, resulting in high intra & inter subject variability & lack of dose proportionality. This can be increased by different methods like salt formation, solid dispersion and complex formation. Self-Emulsifying Drug Delivery System (SEDDS) is gaining popularity for improving the solubility of lipophilic drugs. SEDDS are defined as isotropic mixtures of one or more hydrophilic solvents and co-solvents/surfactants that have a unique ability of forming fine oil-in-water (o/w) micro emulsions upon mild agitation followed by dilution in aqueous media, such as GI fluids.Present review provides an updated account of advancements in SEDDS with regard to its composition, evaluation, different dosage forms and newer techniques to convert liquid SEDDS to solid and also various applications.
Kshitija Khedekar* and Swati Mittal
Department of Quality Assurance, Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai, Maharashtra, India
09 July, 2013
09 August, 2013
16 November, 2013
01 December, 2013