SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM
AbstractAdministration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid based drug delivery system is best approach to design formulation with increased therapeutic benefit for poorly water soluble drug. This review provides recent updates on lipid based drug delivery system with main focus on self micro-emulsifying drug delivery system. Self-microemulsifying formulations are evident to improve the oral bioavailability of hydrophobic drugs due to their efficiency in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Oil, surfactant and co-surfactant also contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted
Article Information
2
443-52
531
2557
English
IJPSR
Seema Pattewar *, Sanjay Kasture, Vishal Pande and Swapnil Sharma
Department of Pharmacy, Banasthali University, Banasthali, Rajasthan, India
tsdpatil99@gmail.com
18 June, 2014
28 August, 2014
17 October, 2014
10.13040/IJPSR.0975-8232.7(2).443-52
01 February, 2016
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