SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM: SPECIAL EMPHASIS ON VARIOUS OILS USED IN SMEDDSAbstract
In pharmaceuticals formulation, poorly aqueous soluble medications are becoming more difficult to administer into dosage form as 40-50% of new chemical entities discovered are reported to be poorly aqueous soluble, preventing appropriate absorption from the GI tract. Oral administration is preferred over other forms of administration due to its ease of administration & painless approach. The main problem in the oral dosage form is poor bioavailability due to aqueous solubility. As a result, formulation scientists are employing several ways to improve the absorption and bioavailability of poorly aqueous soluble medication, which is difficult. The different strategies used are nano-suspensions, complexation, pH modification, solid dispersion, liposome, solid lipid nanoparticle (SLN), Self-Emulsifying Drug Delivery systems (SMEDDS) and other techniques are used. In the last few decades, pharmaceutical research has been highly diversified for self-emulsifying systems: from micrometer to nanometer size. Therefore, (SMEDDS) has gained much attention as it requires a minimum dose, and the API can be protected into the hostile environment in the gut. It also forms the droplet size <100 nm. This article aims to review (SMEDDS) and their pharmaceutical application in drug delivery, with special emphasis on various oils, used.
Mukesh Ratnaparkhi *, Rajnandini Ahire, Hrushikesh Shinde and Shailendra Salvankar
Department of Pharmaceutics, Marathwada Mitra Mandal's College of Pharmacy, Thergaon, Pune, Maharashtra, India.
23 May 2022
09 July 2022
01 August 2022
01 February 2023