SERUM CALCIUM AND PHOSPHORUS LEVELS AND THEIR ROLE IN INFLAMMATION IN TYPE II DIABETES MELLITUS (T2DM)

The purpose of the present study is to focus on comparative analysis between antidiabetic drugs and minerals like calcium and phosphorus to understand their role in inflammation in type 2 diabetes mellitus. The sample size is 500 blood samples of both genders which was divided into 3 groups: A, B, and C. Group A on metformin of daily dosage 500mg consisted of 200 subjects, Group B on other anti-diabetic drugs (Glimepiride) of daily dosage 2 mg consisted of 200 subjects. Both groups A and B had no other complications from diabetes. Group C included controls, consisting of 100 healthy individuals with no history of diabetes. When compared between two drug (metformin and other anti-diabetic drug) groups, the percentages of Serum calcium, phosphorus in both male and female groups were significantly decreased and consequently, inflammatory markers like leptin, IL-6, hsCRP, TNF-α were significantly increased in metformin group rather than who were on another anti-diabetic drug group. Decreased serum calcium and phosphorus levels in type 2 diabetes mellitus who are on metformin drug can be a mediator in inflammatory process which leads to micro and macrovascular complications when compared to another anti-diabetic drug group.