SERUM LEVELS OF SELENIUM IN UNCOMPLICATED TYPE-2 DIABETIC PATIENTS AND HEALTHY INDIVIDUALSAbstract
Selenium (Se) plays a vital role in maintaining the body’s homeostasis. Selenoproteins have been found to play an integral role in the body’s defense against oxidative stress. Type-2 diabetes mellitus is considered as an inflammatory state with high oxidative load and is one of the major chronic diseases prevalent in Pakistan. Serum levels of selenium in type 2 diabetic patients and healthy individuals were determined. The sample size consisted of 120 subjects. Inductively coupled plasma optical emission spectrometry was used for the serum selenium determination. Statistical analysis was done at the confidence interval (CI) of 95%. No significant difference was determined in the mean serum selenium levels of type 2 diabetic patients and healthy persons. Moreover, the studied population was observed to be selenium-replete population. Hence, laboratory evidence for prescribing selenium supplement is of vital importance and requires extreme care irrespective of the involvement of oxidative stress disease.
M. Riaz *, K. T. Mahmood and K. Irfan
Department of Pharmacy, Lahore College for Women University, Lahore, Punjab, Pakistan.
16 March 2014
19 May 2014
05 July 2014
01 October 2014