SHORT TERM (21 DAYS) TOXIC IMPLICATIONS OF PERMETHRIN ON REPRODUCTIVE TISSUES OF MALE SWISS ALBINO MICEAbstract
Permethrin, a member of one of the newest class of insecticides, the synthetic type-I pyrethroids, is very much in use nowadays. Due to its relatively low mammalian toxicity and high photostability, it has earned great popularity. Several reports suggest its endocrine disrupting activity, damaging effect on nervous system, its receptors, and other adverse effects. However, very limited information is available regarding its effect on reproductive organs. It is, therefore, imperative to bridge these lacunae. Hence, the present study was aimed to evaluate the effects of Permethrin on the reproductive tissues of male mice. Permethrin (130 mg/kg body weight) was administered orally for a period of 21 days. Biochemical parameters were assayed in testis, caput epididymis, cauda epididymis, seminal vesicle, and vas deferens of Swiss albino mice. The results showed that Permethrin administration lowered the gravimetric indices and decreased the levels of enzymes involved in the energy metabolism like ATPase, ALKPase, ACPase, and SDH, which may lead to oxidative stress and hamper the overall physiological functions.
Z. Siddiqui, N. Agravat, H. N. Highland and K. R. Desai *
Department of Zoology, BMT & HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.
09 December 2019
17 March 2020
20 March 2020
01 December 2020