SIGNIFICANT ROLE OF HYDROTROPES IN EXTRACTION OF PHYTOCONSTITUENTS- A REVIEWAbstract
A hydrotrope is an organic substance that increases the solubility of surfactants and water insoluble phyto-constituents such as esters, acids, alcohols, aldehydes, ketones, hydrocarbons, and fats in an aqueous solution. These are amphiphilic substances composed of both a hydrophilic and hydrophobic functional groups. The hydrophobic part of the molecule is benzene substituted polar segment while hydrophilic part; polar segment is an anionic sulfonate group accompanied by a counter ion (i.e., ammonium, calcium, potassium or sodium). Hydrotropes, such as sodium alkyl benzene sulfonates and sodium butyl monoglycol sulfate, were used for the selective extraction of water insoluble phyto-constituents by cell permeabilization. Here disruption of the cellulosic cell wall and disorganization of the phospholipid bilayers by the hydrotrope molecules, then dissolution of the cellular contents, appear to be the mechanism of extraction process.
P. P. Dongre*, D. M. Kannur, V. Kosambiya and B. D. Desai
Department of Pharmacognosy, SCES’s, Indira College of Pharmacy, Tathawade, Pune, India
04 December, 2010
21 February, 2011
02 March, 2011
01 April, 2011